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- Zebrafish Danio rerio (Casper)
- Casper fish have low melanin (low pigmentation) making them easy to see neurons, etc.
- Benefits
- Easy breeders, don’t require me to feed them as they live off of there embryonic sacs.
- Affordable.
- Similar neuron structure to humans.
- Easy to treat and at mass quantities.
- ERS solution (embryonic rearing solution)
- Control solution for fish.
- Saline-like solution.
- Co-treatment
- L-DOPA
- A precursor to dopamine that can penetrate the blood brain barrier.
- Effective in manufacturing dopamine.
- Dosage: 10 mM
- MAO-I
- Inhibits the monoamine oxidase (enzyme that degrades dopamine)
- Has unknown effect on descreasing hyperkinesia
- Dosage: 50 µM
- Transfer pipet
- Transferring and changing solutions.
- Probing zebrafish.
- 24 Well Plate
- Light dish
- Used for observing phenotype of control and/or co-treatment.
- Dissecting microscope
- Used for observing phenotype of control and/or co-treatment at a closer magnification.
- Video capture software
- Used to capture footage of the zebrafish showing phenotypic responses.